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DuraSeal is Effective in Stopping Intraoperative Supratentorial CSF Leaks
Testimony of Dr. Peter Nakaji

Listen to a testimony from
Dr. Peter Nakaji

of Barrow Neurological Institute
5 meg. Windows
Media Video

According to literature, supratentorial leak rates are higher than expected. In fact, leak rates range from 6.3%2 to 8.9%3 and are often under reported because the definition of a CSF leak varies: sometimes it includes pseudomeningoceles, but oftentimes the definition only includes overt leaks.
 
DuraSeal addresses CSF leaks, the Achilles’ Heel of cranial surgery
  One of the most challenging and potentially dangerous complications of cranial surgery is postoperative leakage of cerebrospinal fluid (CSF). According to Dan Kelly, MD at UCLA, “CSF leaks remain the Achilles’ Heel of a great neurosurgical operation.” CSF leaks can lead to severe headaches, delayed wound healing, meningitis and death.4
 
Routine DuraSeal Sealant use saves hospitals money
 

According to a recent study by J.A. Grotenhuis, MD at St. Radboud University, The Netherlands, hospital costs more than double when a patient has a CSF leak.2 The average cost of a CSF leak is $27,686.This study illustrates that hospitals would save an average of $1,331 per patient if all patients were treated with DuraSeal Sealant.

   
DuraSeal Sealant provides watertight closure
  DuraSeal Dural Sealant is the only FDA approved cranial sealant. In two separate, prospective, non-randomized clinical investigations of 158 patients, DuraSeal Dural Sealant was
98.7% effective at preventing intraoperative CSF leaks.
   
The risk of a supratentorial leak may be low,
but the pressure to prevent one is high!
 

 

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1. Cosgrove et al. Safety and Efficacy of a Novel PEG Hydrogel Sealant (DuraSeal®) for Watertight Closure after Dural Repair. Presented at the Congress of Neurological Surgeons 55th Annual Meeting, Boston, MA, Oct 2005.

2. Grotenhuis JA. Costs of postoperative cerebrospinal fluid leakage: 1-year, retrospective analysis of 412 consecutive nontrauma cases. Surgical Neurology. 2005 Dec;64(6); 490-493.

3. Sawamura et al. Evaluation of Application Techniques of Fibrin Sealant to Prevent Cerebrospinal Fluid Leakage: A New Device for the Application of Aerosolized Fibrin Glue. Neurosurgery. 1999 Feb;44(2); 332-337.

4. Huges GB et al. Cerebrospinal fluid “leaks” and meningitis following acoustic tumor surgery. Otolaryngol Head Neck Surg. 1982;90:117-125.